Singlet oxygen-producing activity and photodynamic biological effects of acridine compounds.
نویسندگان
چکیده
منابع مشابه
Biological significance of singlet oxygen.
The biological significance of singlet oxygen (1O2), an electronically excited species of oxygen, has been realized only in the last two decades. This was mainly due to the lack of proper methodology to generate this reactive oxygen species (ROS) in pure form and its reactions with biological molecules. Recent studies, using newly developed detection methods, show that 1O2 being generated in ma...
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Photodynamic action/Acridine orange/tRNA/Guanine/Singlet oxygen The photodynamic inactivation of acridine orange (AO)-sensitized tRNA was investigated with respect to the type of photochemical pathways and the base damage leading to the inactivation. The diagnostic tests for singlet oxygen (1O2), namely the enhancement effect of deuterium oxide (D2O) and the inhibition effect by sodium azide, i...
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The toxic effects of gas-phase singlet oxygen, 1O2, on the ciliated respiratory epithelium of hamster trachea have been demonstrated. Tracheal explants treated with 1O2 showed a dose-dependent decrease in cilia beating frequency and focal ciliostasis. A statistically significant decrease in ciliary activity occurred at 1O2 concentrations as low as 154 ppb after a 2-hr exposure. Cytological alte...
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Singlet oxygen is believed to be the species destroying cancerous cells during PDT. An optically-based imaging device for monitoring singlet oxygen production in a tumor was developed and tested in-vivo. ©2008 Optical Society of America OCIS codes: (170.0110) Imaging systems; (170.5180) Photodynamic therapy
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1987
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.35.2478